Killing of Dendritic Cells

Killing of Dendritic Cells

Although we normally think of dendritic cells (DCs; references 1 and 2) as the " initiators " of immune responses and of their activity as confined largely to interaction with naive T cells in secondary lymphoid organs, there is emerging evidence that DCs are also important players in the effector phase of the immune response. Although rare, DCs form a dense network of cells in many tissues suc...

Memory CD8+ T cells protect dendritic cells from CTL killing.

CD8(+) T cells have been shown to be capable of either suppressing or promoting immune responses. To reconcile these contrasting regulatory functions, we compared the ability of human effector and memory CD8(+) T cells to regulate survival and functions of dendritic cells (DC). We report that, in sharp contrast to the effector cells (CTLs) that kill DCs in a granzyme B- and perforin-dependent m...

Dendritic Cells in Transplant Tolerance

Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...

Antigens by Activated Dendritic Cells Cells and Presentation of Released Tumor Peroxynitrite-Dependent Killing of Cancer

Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells.

Dendritic cells (DCs), essential for the initiation and regulation of adaptive immune responses, have been used as anticancer vaccines. DCs may also directly trigger tumor cell death. In the current study, we have investigated the tumoricidal and immunostimulatory activities of mouse bone marrow-derived DCs. Our results indicate that these cells acquire killing capabilities toward tumor cells o...